Purported Benefits of HGH

• Loss of body fat
• Muscle growth
• Bone growth, tougher bones, fracture healing
• Increased energy levels and exercise capacity
• Possible improvement to physical condition
• Possible improvement to immune system

Purported Drawbacks of HGH

• Increase IGF-1 levels - anabolic state, over-active AMP and protein synthesis and reduced lifespan conversely catabolic state, mTor authophagy and under-active AMP and protein synthesis and increased lifespan. 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain, regenerative vs proliferative factors and effects persist beyond administration which suggests theoretically that one need not chronically raise IGF1 every day to benefit. It is an anabolic and implicated with shorten lifespan, so you have to follow up with mTor inhibition and autophagy.

• Left ventricular hypertrophy

Purported Benefits of DHEA

• Benefits related to increases in testosterone and estrogen
• Approved for vaginal atrophy

Purported Drawbacks of DHEA

• Androgenic effects

Hormone therapy TRT or HRT requires injections as the molecules are too big to pass the small intestine, described here are the only known means of oral supplementation of hormones specifically HGH as Ibutamoren (MK-677, Nutrabol) as capsules still a research molecule, Testosterone as Ostarine as capsules still a research molecule or DHEA as capsules which have been available for many years.

DO NOT ABUSE THE DRUGS. If you are too compulsive please do not take drugs.

How do I properly use HGH? What dosage should I take?

Growth Hormone and Aging: Updated Review

There is an effort to stop bone and muscle decline with age as a first treatment of ageing all without adverse health consequences of supposed medication. It is possible and the best candidates either Myostatin inhibitor or Ostarine MK-2866 (not both) with Ostarine in conjunction with gym favourable. Frailty has also been associated with the aging immune system.

Ostarine MK-2866 has recently shown efficacy against loss of muscle mass and function (sarcopenia) and loss of bone mass (osteopenia or osteoporosis) occurs with advancing age, when untreated, represent a major public health problem for the elderly population and may result in loss of independence in later life. Both these conditions are a cause of accidents and hip replacements and may prove avoidable if Ostarine still in clinical trials is deemed safe, requires gym exercise to build extra muscle and bone.

Dosages against sarcopenia and osteoporosis are not dosages used in bodybuilding, the higher the doses the greater the risks. Chronic high doses of steroids in bodybuilding is linked with CVD, heart attacks, enlarged hearts and plaque blockages, coronary artery disease, it also destroys liver, kidneys and pancreas and likely more. However, at the correct dose there are instead health benefits, these correct doses generally do not exceed those naturally present in a 20-30 year old person while bodybuilders have known to inject 100 times those amounts daily. The possibility of safe use and benefits cannot be measured by use in bodybuilding.

The avoidance of hormone therapy was always injections, and the industry has searched to make hormones orally bio-available such as CriticalSorb™ with reported bio-availability of HGH at 49% obtained in the first 2 hours after administration by nasal (1). Unknown how long term use might affect nasal mucosa. The next best was 11.06% in Sprague-Dawley rats (not humans) and some other methods 3.4%. (all relative to sub-cutaneous)

Selective Androgen Receptor Modulators (SARMs), orally bio-available with most still in clinical research stage. SARMs mimic the effects of hormones, the most popular SARMs currently include Ostarine (Enobosarm, MK2866, S22), S23, Ligandrol (LGD-4033), LGD-3033, TT-701, Testolone (RAD-140), and Andarine (GTx-007, S-4), SR9009 (Stenabolic), Ibutamoren (MK-677, Nutrabol) (a segretagogue not a SARM), GW501516 (GW1516, Cardarine, Endurobol), YK-11. SARMS are mainly targeted towards building muscle and bone density without androgenic effects. SR9009 differs as it facilitates weight loss. SR9009 has the ability to make your body respond as if it were in a state of constant exercise, increasing the basal metabolic rate and also modifies mitochondria.

Ibutamoren (MK-677, Nutrabol), is a human growth hormone (HGH) secretogogue. It crines the pituary gland to produce more growth hormone. Human growth hormone has been associated with many health benefits, increased HGH comes with increase in IGF-1, Insulin like growth factor one levels. Rise in insulin is associated with shortened lifespan and associated with the Western diet, cadiovascular disease and diabetes. IGF-1 is also believed to shorten lifespan.

MK-677, reports the growth hormone releasing hormone GHRH (MK677) Ibutamoren may get suppressed, desensitized after some months of use as the hypothalamus senses and increases somatostatin 1. The conclusion reads quote: Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST (somatostatin) in the hypothalamus. Further studies are needed to overcome the observed desensitization.

We require to manage these issues towards a safe protocol.

• Manage increased IGF-1 levels.
• Manage somatostatin.
• Left ventricular hypertrophy

Low Insulin Diet, IGF-1

Lower insulin production to compensate for raised IGF-1 and all being equal, come out better off. The worst diet is malnutrition, second worst diet is the western diet. The western diet is a high insulin diet. High insulin diets cause heart attacks, strokes, (CVD cardiovascular disease), organ failure, diabetes. A low insulin diet therefore is preventative against all cause mortality. Opting towards a low insulin diet will increase health span and life span, the western diet and diabetes is crystal clear about this. Insulin is not the bad guy, food in the blood destroys the organs, liver, kidney and also the heart and brain and high insulin production means you are eating way too much and overloading your organs and cells.

Taking HGH (MK-677) causes an increase in insulin like growth factor 1 (IGF-1) levels for 24 hours after administration. We need to understand how much insulin we are producing and how much IGF-1 we are producing. We can no longer have ignorant crazy soda spikes every hour or thousands of calories in 5 minutes. HGH works with IGF-1 and insulin to remodel the body. How much protein and sugars do we want to give the anabolic state? And do so in the healthiest way possible with the lowest load on the organs.

A low insulin diet is believed to extend lifespan to its maximum by itself for several reasons and its primary indicator is the amount of insulin production required of the pancreas.

You must get this right and understand what is being stated here.

• Diabetics have permanent raised insulin levels.
• High insulin levels have been associated with shorten lifespan.
• Insulin resistance has been associated with diabetes, stroke, heart attacks, multiple organ disease and failure, and more.
• Insulin is NOT just about sugar, all foods except water trigger the production of insulin.

1. What is the minimum amount of food that is a nutritionally complete diet. Eat at one sitting.
2. Be nutritional complete, vitamins, minerals, amino-acids using the lowest glycaemic index and insulin index foods only. Do not malnutrition in preference to low insulin. Malnutrition is the worst diet.
3. Be on an 20/4 eating window, so that organs rest during off time and overnight and no insulin is produced during the fast.
4. Do not eat in excess.
5. Time restriction eating.
6. Take most sugars, fructose out of the diet. Once fruits are processed, the fruit juice is basically all sugar. Eat real food, there is no soda spring.
7. Take refined carbohydrates out of diet. Once raw wheat is refined, the result is basically all sugar that is bread. Eat real food, there is no cake tree.
8. Avoid foods that drive inflammation.
9. Do insulin resistance reversing practices such as exercise.
10. The insulin index and to a lessor extent the glycaemic index are the authority on low insulin diet.
11. Think about the low insulin, nutritionally complete diet regime.
12. Stay out of hypoglycaemia, hypoglycaemia, and insulinemia.
13. Work on nutrition, live on a low insulin diet before taking HGH or any other hormones.

The insulin index informs that not only does sugar raise insulin levels but non-sugary foods also raise insulin levels. This means a low glycaemic diet may still be a high insulin diet. Ideally you have the minimum amount of food that is nutritionally complete and that is eaten in one meal and that ends eating for a 20-hour period, water excluded and not strictly. In an attempt to NOT have raised insulin on top of raised IGF-1 in an extreme western way. Insulin is necessary and performs important roles in the human body.

Insulin Index

If you drink sugar you spike your insulin, if you drink sugar all the time then you are constantly spiking your insulin, this situation causes type 2 diabetes, strokes and cardiovascular disease, because MK-677 raises IGF-1 levels we require minimal insulin production by diet alteration. You will need to re-make your diet and live like you are a type 2 diabetic before experimenting with HGH and DHEA. We are going to do this without diabetes drugs, within the limits of the human body and that means getting the diet work right. It can take up to 12 months to reverse insulin resistance, and you have been causing it for many years.

Managing Somatostatin Naturally

Achieved by periodic use of MK-677, 25mg - 1 time per 7 days or 25mg - 1 time per 5 days. Cease use for somatostatin to return to normal and then dose again.

Left Ventricular Hypertrophy

Left ventricular hypertrophy is a thickening of the wall of the heart's main pumping chamber. This thickening may result in elevation of pressure within the heart and sometimes poor pumping action. The most common cause is high blood pressure.

Log your blood pressure and if it rises with HGH use, lower the dosage or cease use.

It is unknown what dose may lead to LVH. Bodybuilders are taking 100 times normal doses of many substances, and they suffer heart attacks and organ failure in their late 20s onwards, clearly shortening lifespan. Dosage is important, too little and no action, too much and chronic use and complications so it is believed that doses kept within normal, those not exceeding 20-30 year olds once or twice a week are safe. It may be possible that a sweet spot dose is beneficial to heart function noted from heart function of GH deficient and heart function related to bodybuilders. Acromegaly shows LVH vs. GHD Growth Hormone Deficient supplementation shows no LVH alluding to depends on dose.

Growth hormone status predicts left ventricular mass in patients after cure of acromegaly

Controversies Regarding the Effects of Growth Hormone on the Heart

Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure

Growth hormone: a newcomer in cardiovascular medicine

Is growth hormone good for the heart?

Cardiovascular effects of high-dose growth hormone treatment in growth hormone-deficient children

Toxicity

When taking medications or eating too much there is load on organs and risk of toxicity and damage. The production of IGF-1 is done by the liver and the production of insulin is done by the pancreas, liver health, pancreas heath, kidney health, digestive system health.

• Drink plenty of water to flush toxins, maintain light yellow urine. Like many medications the drugs may create toxins and enzymes in the liver and other organs so drink plenty of water to flush these out.
• Use an eating window such as 18/6 or 20/4 to allow 18 hours for digestive system to rest and repair, water excluded as water is a cleaning agent.
• Eliminate non-necessary medications.
• Not more than 40ml of alcohol per day.
• Rinse fruit and vegetables and find pesticide free foods.
• Drink a coffee, short black no sugar. (1)
• Get vaccinated for hepatitis.
• Do not smoke.
• Avoid refined sugar, high fructose corn syrup, trans fat. Bad sugar is the "added" sugar and it is usually overdosed. These foods are not real foods. An apple is a real food while "fruit bars" or "apple juice" are not real food. Water is a real food, "Vitamin Water" or "Coca Cola" is not a real food.
• 2 raw eggs per day aids the liver.
• Cruciferous vegetables like broccoli and brussels sprouts.

The Protocol

Certain activities raise HGH naturally (1). The two major activities is high intensity exercise, sleep and intermittent fasting. Before of after exercise supplement with HGH, if adding Osterine do so before gym and before bed supplement with DHEA.

The three products in the bio hack are MK-677, MK-2866 or DHEA. Limit MK-677 and MK-2866 to once a week before gym while DHEA supplement seems to be mild, fake or does nothing, 50 mg before bed or whenever. MK-677 start on 3mg and increase as desired but do not exceed 25 mg, once a week or every five days. HGH works on IGF-1 and insulin, MTOR anabolic and requires proteins (to build) and fats (for energy). Take care to keep insulin and IGF-1 in healthy levels at all times. Do NOT do every day allow the human body some days to return to normal.

DO NOT ATTEMPT THIS IF YOU DID NOT UNDERSTAND THE INSULIN - IGF-1 SITUATION

Discontinue use or lower dosage with side effects.

MTOR Inhibition versus Anabolic

A differing effect or taking androgens in an MTOR inhibited state versus an anabolic state, when the human body is in an anabolic state it builds tissue, but when the human body is under MTOR inhibition and receives androgen does its function change?

No Way To Measure Blood Insulin

Ideally one would grade their lifestyle by an ongoing measurement of insulin production. There is no way to measure blood insulin easily, ideally a person would either measure insulin levels at intervals, after meals or have a permanent measure and then be able to note the reason for alterations in the insulin and proof that diet is normal insulin.

As there is no way to monitor blood insulin levels we can only rely on the insulin index, the glycaemic index and glycaemic load. Not eating generally does not trigger insulin production, so I guess time restricted eating.

The proposed non-invasive blood glucose monitor seek to be diabetic use quality, but we do not require precise reading. Such a product is gluco-wise, https://gluco-wise.com/, these measure blood sugar levels and would be a useful device. While useful the crux of the matter is too much unnecessary insulin production because of diet and eating habits. The food eaten initiates insulin production, and we require a diet that is nutritionally complete but requires minimal, normal, healthy insulin production to offset raised IGF-1 levels.

Foods that have no sugar can also spike insulin levels and a glucose monitor is useless for such applications. The reality is all foods except water generates an insulin response.

Diabetic use A1C test is a long term test of blood sugar.

The dosage and frequency of safe MK-677 usage is limited by insulin and IGF-1 levels. Measuring IGF-1 levels cannot be done at home. The IGF-1 Blood Test is also known as SM-C/IGF-1, Somatomedin-C, and Sulfation Factor. No fasting is required for this test, unless instructed to fast 10 to 12 hours before, and results will be delivered within 1-2 days. Some home tests similar to finger prick has been seen online but never tried.

Most likely rely on trials that have supplemented people and then measured there levels and then assume your dosages are doing the same to you.

While removing glucose from diet as a means to avoid insulin spike, that is not the whole story. It is a low, normal, healthy insulin diet relative the insulin index not just blood sugar. A fasting blood glucose test will show your fasting blood sugar level. You'd have this test done after not eating or drinking for at least eight hours. Fasting blood sugar levels under 100 milligrams/decilitre (mg/dL) are considered normal. Levels between 100 and 125 mg/dL indicate prediabetes. Levels equal to or greater than 126 mg/dL are diagnostic for diabetes. These numbers could vary up to 3 mg/dL points in the cut-off numbers. You will also want to test your meals for healthy insulin waveforms and not spikes and change out foods and beverage to improve performance.

Two-hour glucose tolerance test, Your blood glucose level is determined before this test begins. You'll then receive a pre-measured sugary drink and your blood glucose level is checked again in two hours. A blood sugar level after two hours of less than 140 mg/dL is considered normal. A result between 140 mg/dL and 199 mg/dL is considered prediabetes. A blood sugar level of 200 mg/dL or higher is considered diabetes.

Low blood sugar (hypoglycaemia): sweating, feeling tired, dizziness, feeling hungry, tingling lips, feeling shaky or trembling, a fast or pounding heartbeat (palpitations), becoming easily irritated, tearful, anxious or moody, turning pale. Further on, weakness, blurred vision, confusion or difficulty concentrating, unusual behaviour, slurred speech or clumsiness (like being drunk), feeling sleepy, seizures or fits, collapsing or passing out.

High blood sugar (hyperglycaemia): increased thirst and a dry mouth, needing to pee frequently, tiredness, blurred vision, unintentional weight loss, recurrent infections, such as thrush, bladder infections (cystitis) and skin infections, tummy pain, feeling or being sick, breath that smells fruity

HGH makes children grow so the side effects of taking HGH could be joint and muscle pain, increased insulin resistance, swelling in the arms and legs, for men enlargement of breast tissue (gynaecomastia), carpal tunnel syndrome. If you notice any of these then discontinue use. My personal side effects, body pains, joint pains momentary or pulsing, kept awake all day while feeling tired all day, good mental state but apathetic, cold hands or cold feet, disinterested, disorientated, discomfort to focus, prefer to lay down, stomach discomfort or upset, diarrhoea.

IGF-1 Levels

Shows typical results of dose of MK-766 in HGH and IGF-1 levels, overlay with your age. Indicates a dose between 2mg and 10mg. The 2mg dose might still produce a early spike but low dose is easily cleared from the body before 24 hours.

Growth Hormone-Releasing Hormone and Growth Hormone Secretagogues in Normal Aging

Aiming for 21-30 levels after resistance training. Three independent seperate graphs.

Source for bottom graph https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185561

Testing Products

Insulin-Like Growth Factor (IGF-1) (Somatomedin Test Kit

IGF-1 elisa kit :: Human Insulin-Like Growth Factor 1 ELISA Kit

Insulin-Like Growth Factor I (IGF-1) Home Health Test Kit - Blood Spot

Research programme: somatropin oral - Access Pharmaceuticals - https://adisinsight.springer.com/drugs/800031485,

Access continues to make significant progress with its proprietary CobOral delivery technology. Access' CobOral product development program initially focused on the oral delivery of insulin and human growth hormone (hGH), two peptides which currently can only be given by injection. Since presenting promising results at a major conference in mid-2008, Access has made substantial improvements to the formulation technology. An improved CobOral insulin-containing nanoparticle formulation delivered orally provided a pharmacological response (lowering of blood glucose levels in an animal model of diabetes) equivalent to greater than 80% of that achieved by insulin delivered subcutaneously. This represents a substantial oral bioavailability, indicating that this formulation has potential for clinical development and ultimate commercialization. Adaptation of this technology has provided a CobOral hGH formulation that has demonstrated good efficacy, represented by more than 25% improvement in weight gain, when given orally in an established animal model.

Oral delivery of human growth hormone: Preparation, characterization, and pharmacokinetics

In the present study, to increase the oral bioavailability of growth hormone and improve patient compliance, enteric-coated capsules filled with monomethoxyl poly(ethylene glycol)-b-poly(L-lactide-co-glycolide) nanoparticles were prepared to facilitate oral growth hormone delivery. The nanoparticles were less than 100 nm in size, exhibited narrow polydispersity indices < 0.3, and showed a zeta potential of -4.87 mV. The highest efficiency of growth hormone encapsulation achieved in this study was nearly 70%. An in vitro release experiment showed that adequate amounts of growth hormone were retained under simulated gastric conditions and significant amounts of growth hormone were released under simulated intestinal conditions. The bioavailability of encapsulated growth hormone relative to subcutaneously injected growth hormone in Sprague-Dawley rats was 11.06%. Thus, the use of poly(ethylene glycol)-b-poly(L-lactide-co-glycolide) nanoparticles yielded promising results, and these agents should be investigated further regarding their potential as an oral growth hormone delivery system in the future.

Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole

Liposomes for the oral delivery of human growth hormone (hGH) containing bio-enhancers and tetraether lipids were prepared by dual asymmetric centrifugation. Cetylpyridinium chloride (CpCl), d-α-tocopheryl polyethylene glycol 400 succinate, phenylpiperazine, sodium caprate or octadecanethiol were used as permeation enhancers. In vitro data showed that oligolamellar vesicles with average size in the range of 200-250 nm were formed. Performance of the formulations was investigated both ex vivo by confocal microscopy scans of sections of rat small intestine and in vivo by comparing the area under the plasma curve of hGH after oral or subcutaneous (s.c.) application. The microscopic data reveal an interaction between the liposomal formulation and the intestinal mucus layer. Particularly one formulation, which was designed to be mucus penetrative by addition of a high quantity of TPGS 400 and a ζ-potential close to 0 mV, showed a very strong mucus association in the duodenum and jejunum. Vesicles with CpCl 33% (mol/mol) led to a relative hGH bioavailability of 3.4% compared with s.c. control, whereas free hGH administered orally showed a bioavailability of only 0.01%.

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats

Suggests that MK-677 stops working after a period of use...

Oral administration of MK-677 at 4 mg/kg increased peak GH concentrations by 1.8-fold, compared to baseline. However, oral administration of MK-677 for 6 weeks did not increase body growth or serum levels of IGF-I. At 6 weeks after treatment, the GH response to MK-677 was abolished. Pituitary GH mRNA and hypothalamic GH-releasing hormone mRNA, and GH secretagogue receptor (GHSR) mRNA expression in the pituitary and hypothalamus did not differ between the control and treatment group. Somatostatin (SST) mRNA expression in the hypothalamus was markedly increased in the treatment group, whereas SST receptor (SSTR)-2 mRNA expression in the pituitary gland was decreased

Further studies are needed to overcome the observed desensitization to GHS.

See Somatostatin, inhibits GH inhibition.

https://www.fortexpharma.com/nutrabol

Oral Administration of Growth Hormone GH Releasing Peptide-Mimetic MK-677 Stimulates the GH-Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults

Patents - https://patents.google.com/patent/RU2493868C2/en, https://patents.google.com/patent/US8323688B2/en

https://www.researchgate.net/publication/263709483_Formulation_strategies_to_improve_oral_peptide_delivery

Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone

Intranasal Human Growth Hormone (hGH) Induces IGF-1 Levels Comparable With Subcutaneous Injection With Lower Systemic Exposure to hGH in Healthy Volunteers