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Erectile dysfunction is commonly caused by either vascular damage or andropause, hormone decline assocaited with aging. Recently the wandering spider is known to cause erections when stung, some scientists have claimed to have isolated the molecule that causes the erections. Tx2-6 is a toxin found in the venom of the Brazilian wandering spider, Phoneutria nigriventer (Keyserling). It is a peptide of 48 residues, molecular weight 5291.3. This peptide is cleaved from a longer precursor with a signal peptide and a glutamine-rich propeptide. It can cause priapism. Recent studies have isolated the brain circuit that controls libido and erections, the brain is the start of the axis and age related changes in the brain could be the predominant reason for erectile dysfunction. Med3000

1. https://med.stanford.edu/news/all-news/2023/08/male-libido-brain.html
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035689/
3. https://academic.oup.com/jsm/article-abstract/7/12/3879/6848021?redirectedFrom=fulltext

If low T is the cause, then a bood test would indicate so and testosterone gels or patches could make a difference. DHEA is bio-available oral.

Several foods are nitric oxides boosters such as beets, spinach and should be eaten everyday. In supplement...

• L-citruline, could be more effect than L-arginine
• French maritime bark extract aka pycnogenol
• Agmatine, yet studies are lacking.

Traditionally...

• Panax ginseng: Also known as Asian ginseng, this herb has been traditionally used to improve sexual function. Some studies have suggested that it may improve erectile function and sexual satisfaction in men.
• Maca root: This herb is traditionally used as a natural remedy for improving sexual function and libido. Some studies have suggested that it may improve sexual function and desire in both men and women.
• Yohimbe: This herb is derived from the bark of an African tree and is traditionally used as an aphrodisiac. Some studies have suggested that it may improve erectile dysfunction, but it can also have potential side effects, including increased heart rate and blood pressure.
• Tribulus terrestris: This herb is traditionally used as a natural remedy for improving libido and sexual function. Some studies have suggested that it may improve sexual desire and satisfaction in men with erectile dysfunction.
• Ginkgo biloba: This herb is believed to have potential benefits for improving blood flow and may have potential effects on sexual function. Some studies have suggested that it may improve erectile dysfunction and sexual satisfaction.
• Nitric oxide: L-arginine is an amino acid that the body converts to nitric oxide, a molecule that helps to relax blood vessels and improve blood flow. Some studies have suggested that L-arginine supplementation may improve erectile function in men with erectile dysfunction.
• Zinc: Zinc is an essential mineral involved in numerous bodily functions, including testosterone production. Low levels of zinc have been associated with sexual health issues, so ensuring adequate zinc intake may be beneficial. Zinc is involved in testosterone production. Vitamin B12, and omega-3 fatty acids also play important roles in maintaining hormonal balance. Magnesium is another mineral involved in hormone regulation.
• Carnitine helps to transport fatty acids to the penis, which is necessary for an erection.
• Pycnogenol: Pycnogenol is a patented extract derived from the bark of French maritime pine trees. It has antioxidant and anti-inflammatory properties and has shown potential in improving erectile function.
• Vitamin D is important for sperm health.
• Fenugreek (Trigonella foenum-graecum) is an herb that has been suggested to have effects on testosterone levels. Some studies have explored the relationship between fenugreek supplementation and testosterone, but the results are mixed.

1. Alprostadil topical cream, Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review, Alprostadil cream in the treatment of erectile dysfunction: clinical evidence and experience

Research pathways for erectile dysfunction (ED) or low libido...

• Novel PDE5 Inhibitors: Explore the development of new compounds that target the phosphodiesterase type 5 (PDE5) enzyme, similar to existing drugs like sildenafil (Viagra) and tadalafil (Cialis). These drugs work by increasing blood flow to the penis, aiding in erectile function.
• Nitric Oxide Enhancers: Investigate substances that can enhance the production or bioavailability of nitric oxide, a molecule involved in penile blood vessel dilation and erectile function. Enhancing nitric oxide levels can potentially help with ED. For example, compounds that stimulate nitric oxide synthase or act as nitric oxide donors could be explored.
• Testosterone Modulators: Assess substances that can modulate testosterone levels, which play a crucial role in sexual desire and function. Investigate potential compounds that can optimize testosterone production, uptake, or receptor activation to address low libido or ED caused by low testosterone levels.
• Neurotransmitter Modulators: Explore substances that target neurotransmitters involved in sexual arousal and desire, such as dopamine and serotonin. Investigate compounds that can enhance neurotransmitter release, inhibit reuptake, or modulate receptor activity to potentially improve libido and sexual function.
• Herbal Extracts and Natural Compounds: Investigate the potential of various herbal extracts or natural compounds that have been traditionally used to address sexual health issues. Examples include ginseng, horny goat weed, maca root, or tribulus terrestris. Scientifically assess their effects on ED or low libido through in vitro and animal studies, and eventually clinical trials if initial results are promising.
• Combination Therapies: Consider exploring combinations of different compounds or substances to target multiple pathways involved in erectile function or libido. For example, combining a vasodilator with a testosterone modulator or a nitric oxide enhancer may have synergistic effects.