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The two major issue with O.I. are keeping the neurons alive and communication. Electrophysiology in O.I. is the study of neuron's electrical system for the result that communication methods can be formed.

There are two known communication system in the human body, chemical and electrical.

This language changes the mode of the cell, initiates a function from its DNA manifold.

O.I. and building sensory systems. The technology is development of retinal stimulation system using artificial retina that turns light to electrical signals, such as the Argus II which is a retinal prothesis. Cochlear implants, that turn sound waves into electrical signals. These protheses work in the same way, to the production of a convertor that turns the real world into electrical signals. These are the right signals to send to an organoid as they mimic real world senses. There is evaluation based on the real world senses. Essentially a prosthetic is sound, the electrical signal neurons produce to move our mouths to produce sound, taking those modulating signals and putting them through a speaker.

This takes much of the guess work out of the situation, we know the class of inputs they are receiving as we can compare that with the sensory brain interface in humans, eliminating non-essential intermediaries.

Along with developing an artificial sensory system that have medical applications. There is currently a simpler system of stimulation and response, re-enforcement learning.

Such a complex partitioning could be termed, brain targets. Some parts of the organoid are targeted for visual, others for hearing.