An Inside Look at Retinal Prosthesis Technology
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Raymond Iezzi, MD, MS, Rochester, Minn.
Published 22 April 2010
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Early retinal prosthetic devices are currently in clinical trials and are demonstrating exciting results.
Retinal prosthesis technology is currently under development in more than 13 centers across five continents worldwide. Consequently, there are significant differences in the technology and stages of development across groups.
Patients with advanced retinal degenerative diseases and their family members often actively seek information related to the latest neuroprotective treatments to slow their disease progression or rehabilitative technologies that may restore their sight. Retinal physicians are faced with the task of explaining to patients the state of retinal prosthesis technology, when it will become practical and what level of vision might be restored. While this may seem daunting, a systematic approach to categorizing retinal prosthesis technology greatly simplifies an understanding of the field.
Retinal Prosthesis Types
A retinal prosthesis is a device that gathers visual information with an electronic detector, then processes and converts that image into a form of stimulation that the retina and brain can interpret as a form of vision. All retinal prostheses can be categorized according to three fundamental design features—detector type, stimulation type and stimulation site.
Detector Type
Detectors for retinal prostheses can vary from the CMOS or CCD chips found in webcams or camcorders to microphotodiodes that act as tiny solar cells, turning light directly into electrical current. This distinction is important because CMOS and CCD devices require an external power supply, and microphotodiodes do not. Consequently, at the present time, CMOS or CCD cameras are mounted to eyeglass frames, external to the body. They are used to collect video images that are, in turn, processed by a small computer worn near the waist. This processor identifies important features of the visual environment such as object edges and sends a reduced form of the image to a receiver/stimulator "chip" implanted within the body that receives the wireless transmission and in turn stimulates the retina according to the device stimulation type.
Microphotodiodes, however, are often im-planted within the eye and rely upon the cornea and lens to focus the light upon them. Patients with these implanted sensors can be refracted to improve device performance. In addition, since microphotodiodes are manufactured on a microscale, they are often each integrated with their own stimulation site. Consequently, retinal prostheses employing these devices often comprise thousands of stimulators as compared to systems that rely on external detectors that presently employ fewer than 100 stimulators. In addition, while systems that use eyeglass-mounted cameras require patients to scan their environment using head movements, implanted microphotodiode array systems allow patients to employ natural eye movements and higher level cortical circuits to redirect their visual attention.
Stimulation Types
- Electrical Stimulation. The vast majority of retinal prostheses in development today employ electrical current to stimulate the retina, producing electrophosphenes. These are small, round, oval or elongated spots of light produced when pulses of electrical current are applied to the retina.1-3 This form of stimulation was originally employed in cochlear implants that deliver electrical current via multiple linearly arranged electrodes that stimulate the cochlea to restore hearing. The challenge faced by retinal prosthesis designers is the fact that significantly greater amounts of data are conveyed visually, creating a bandwidth bottleneck. Since electrode arrays are arranged as two-dimensional matrices (See Figure 1), significantly more electrodes are required to restore vision than to restore hearing. In addition, to achieve better visual acuity, electrodes must be small in diameter and closely spaced. Small diameter electrodes have a greater tendency to break down water into hydrogen peroxide and may fail during stimulation when greater amounts of electrical current are needed. This can occur in cases where the retinal degeneration is severe or when the electrode array is not in close apposition to the retina.
- Neurotransmitter Stimulation. In an effort to develop a more naturalistic method of retinal stimulation, the collaborative groups at Wayne State University and Mayo Clinic are designing methods for delivering neurotransmitters to the retinal neurons using microfluidic technology.4 This approach leverages natural chemical visual channels within the retina, and can stimulate or inhibit neuronal firing, forming the basis for visual contrast. This technique employs the controlled delivery of neurotransmitters to the retina in space and time, analagous to way an inkjet printer puffs ink onto paper. The stimulation sites within the device (See Figure 2) may be constructed to be orders of magnitude smaller than stimulating electrodes. Consequently, this technology may offer higher resolution at future stages of development.
Stimulation Site
- Epiretinal. The most critical component of the retinal prosthesis system is the tissue interface formed at the junction of the neurosensory retina and the stimulator. Retinal prosthesis designers interface to either the epiretinal surface or the subretinal surface, for a variety of reasons. Epiretinal devices are placed in very close proximity to the internal limiting membrane, where retinal ganglion cells may be stimulated directly or indirectly via bipolar cell synapses. Epiretinal placement is achieved after pars plana vitrectomy with removal of the posterior hyaloid. Fixation is via a retinal tack. The greatest challenge associated with epiretinal placement and fixation is assuring that the stimulator is in very close proximity to the retina over the entire extent of the stimulation site.5,6 Otherwise, large areas of the visual field covered by the prosthesis will remain non-functional. Close apposition between the stimulator and the retina may be difficult in cases where the stimulator cable introduces mechanical torque at the tissue interface. Epiretinal stimulators are less surgically complex to place and remove as they do not require surgical detachment of the retina and transchoroidal subretinal insertion.
- Subretinal. Subretinal placement assures close proximity to the neurosensory retina and obviates the need for tack fixation as the retina is draped over the stimulation sites. The surgical approach is more complex, however, requiring a pars plana vitrectomy, formation of a localized retinal detachment bleb and trans-scleral, trans-choroidal incisions for the ab-externo insertion of the stimulator into the subretinal space. After insertion, the retina is re-attached via internal tamponade.7