Aspirin has been shown to extend lifespan in mice, by either its anti-inflammatory effect or its anti-blood clotting effect.

Aspirin works by irreversibly inhibiting an enzyme called cyclooxygenase (COX). COX is involved in the production of prostaglandins, which are chemicals that cause pain and inflammation. Aspirin also inhibits the production of thromboxane A2, which is a substance that promotes platelet aggregation. Platelets are blood cells that help to clot blood. When aspirin blocks the production of thromboxane A2, it can lead to bleeding.

Aspirin can cause stomach bleeding and ulcers. If you are considering taking aspirin for longevity or to prevent age-related diseases, talk to your doctor first. They can help you to determine if aspirin is right for you and can help you to manage any risks. Enteric-coated aspirin is coated with a substance that prevents it from being absorbed into the bloodstream until it reaches the small intestine.

Nattokinase is thought to be able to replace aspirin without adverse effect, studies are pending.

For longevity, it is thought to take a low dose aspirin every other day or longer.